The coenzyme your cells can't work without.
NAD⁺ — nicotinamide adenine dinucleotide — is found in every living cell. It's a coenzyme involved in hundreds of reactions, sitting right at the centre of how your body turns food and oxygen into usable energy.
Think of it as the current running through your cellular wiring.
Energy
Powers the conversion of food and oxygen into ATP — the energy currency your cells spend every second of every day.
Repair
Acts as a required substrate for the enzymes that repair the everyday DNA damage your cells accumulate.
Signalling
Activates sirtuins — a family of genes involved in how cells regulate stress, metabolism, and ageing.
It falls as you age — quietly, and often faster than you'd think.
Research suggests intracellular NAD⁺ can fall by roughly half between young adulthood and midlife. Age sets the baseline — but how you live shapes the slope.
Schematic of the well-documented age-related decline in cellular NAD⁺. Your real curve depends on your biology — which is why it's worth measuring.
When the current drops, your systems feel it.
NAD⁺ powers the same core machinery in very different tissues — so as levels fall, the effects can surface across the body. Researchers have linked declining NAD⁺ to changes in several systems.
What low NAD⁺ can feel like, day to day
Heart & circulation
The heart is one of the body's most energy-hungry organs. NAD⁺ fuels the mitochondrial ATP that keeps heart muscle contracting and supports the pathways that protect blood-vessel function. Low NAD⁺ is associated with the “energy-poor” state seen in cardiovascular ageing.
Metabolic & energy
Every step of turning food into fuel depends on NAD⁺. As it declines, cells handle glucose and fat less efficiently, and low-grade inflammation can rise — a pattern associated with metabolic ageing and reduced cellular resilience.
Brain & cognition
Neurons are dense with mitochondria and rely on NAD⁺ for both energy and DNA repair. Declining NAD⁺ has been associated with brain fog, slower processing, and the cognitive changes that come with ageing.
Skin & recovery
NAD⁺ supports the repair crews that fix daily cellular wear — in skin, muscle, and beyond. Lower levels are associated with slower recovery and the visible and felt signs of cellular ageing.
These are associations described in research — not diagnoses. NAD⁺ is a marker we measure to understand your cellular health; it is not a treatment for any condition.†
Why a normal blood test can still miss the truth.
Standard tests capture only the small, fluctuating fraction circulating in plasma — the fuel in the hose, not the fuel in the tank. To see what your cells actually have to work with, you measure intracellular NAD⁺.
Blood / plasma NAD⁺
5–10%The "fuel in the hose." A small, highly variable fraction that doesn't reflect what's happening inside your cells.
Intracellular NAD⁺
90–95%The "fuel in the tank." The stable, clinically meaningful pool where your energy, repair, and longevity pathways actually run.
Measure the tank — not the hose.
Test. Optimise. Track.
Measurement turns supplementation from a guessing game into a personalised protocol that evolves with you.
Test
A simple at-home fingerprick measures your intracellular NAD⁺ and sets your personal baseline.
Optimise
A replenishment protocol and precision supplements, matched to your measured levels — not a generic dose.
Track
Retest each quarter to see what's changing — and adjust your protocol from real data, not guesswork.
Understand your cellular energy before you try to change it.
Beyond average. Beyond assumption. Begin with what's measurable.
Measure your NAD⁺